ANTI-INFLAMMATORY AND ORAL TOXICITY ASSESSMENT OF R-38TM: A TRADITIONAL HERBAL SUPPLEMENT FOR ARTHRITIS

R-38TM is a traditional herbal supplement for treating arthritis-related conditions. High-performance liquid chromatography (HPLC) analysis was performed identification and quantification of rosmarinic acid in the water extract. The anti-arthritic potential extract investigated by measuring production IL-6 TNF-α inflamed cells. Xanthine oxidase (XO) cyclooxygenase-2 (COX-2) inhibition assays were also conducted. cytotoxic effect on HSF1184 cell line. Acute subacute oral toxicity studies conducted female Sprague-Dawley (SD) rats. identified at 1.208 min (3.61 %w/w). cells showed decrease (55.9%) (52.13%). COX-2 XO enzymes moderately inhibited cytotoxicity no cell. acute revealed mortality normal body weight all doses. There significant differences (p > 0.05) organ weight, hematological biochemical parameters, histology liver kidneys with control group. In conclusion, exhibited toxic orally may possess therapeutic properties against pro-inflammatory diseases including arthritis.